Outpacing Infectious Disease
Abstract
The Outpacing Infectious Disease thrust will investigate fundamental methods for using biology as a technology to create adaptive therapeutic response mechanisms to outpace viral diseases. Today, protective measures such as antivirals and vaccines are often circumvented by fast-mutating viruses that evolve to develop drug resistance. New approaches, such as enabling co-evolution and co-transmission of newly developed therapeutics to ultimately outcompete the pathogen, are needed in vaccine and antiviral design. Key advances expected from this research include identifying methods to discover and develop new classes of dynamic therapeutics for fast-mutating viruses. This approach represents a significant departure from conventional antiviral therapies, which typically rely on static solutions and continuous re-formulation and re-development in attempt to keep pace with emerging strains and disease variants. Advances in this area may be applied to the mitigation of known, new, or emerging diseases.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2018
- Source ID
- 01519eaf73e68929a2774a3e63ec6dbe