Applied Biomedical Technology

Abstract

For the Guidance for Development of the Force - Applied Biomedical Technology: This applied research funding is to refine concepts and ideas into potential solutions to military health and performance problems, with a view towards evaluating technical feasibility. Included are studies and investigations leading to candidate solutions that may involve use of animal models for testing in preparation for initial human testing. Research in this Program Element (PE) is designed to address the following: Areas of interest to the Secretary of Defense regarding Wounded Warriors, capabilities identified through the Joint Capabilities Integration and Development System, and sustainment of priority investments in science, technology, research, and development as stated the strategy and initiatives described in the Quadrennial Defense Review. Program development is peer-reviewed and fully coordinated with all Military Services, appropriate Defense Agencies or Activities, and other federal agencies, to include the Department of Veterans Affairs, the Department of Health and Human Services, and the Department of Homeland Security. This coordination occurs through the planning and execution activities of the Joint Program Committees (JPCs), established for the Defense Health Program (DHP) Research, Development, Test and Evaluation (RDT&E) funding. Research supported by this PE includes hemorrhage (bleeding) and resuscitation, diagnosis and treatment of brain injury, treatments for extremity trauma (injury to tissue, head, face, jaw, and mouth, lungs, and burns), forward surgical intensive critical care, and en route care. Operational medicine efforts focus on injury prevention and reduction, psychological health and resilience, physiological health, and environmental health. Rehabilitation applied research focuses on neuromusculoskeletal injuries, pain management, regenerative medicine and sensory systems. Applied research efforts are also developing radiation medical countermeasures. And, within the area of military infectious diseases, applied researchers focus on wound infection prevention and antimicrobial countermeasures. As research efforts mature, the most promising efforts will transition to technology development (PE 0603115HP) or advanced concept development (PE 0604110HP) funding. For the Army Medical Command, beginning in FY14, the military HIV research program funding is transferred from the Army to the Defense Health Program. Work in this area includes refining improved identification methods to determine genetic diversity of the virus, preclinical work in laboratory animals including non-human primates to identify candidates for global HIV-1 vaccine, and evaluating and preparing overseas sites for clinical trials with these vaccine candidates. For the Army Medical Command, beginning in FY15, funding is provided to develop strategies to prevent, mitigate, and treat antibiotic resistant bacteria in wounds through the Combating Antimicrobial Resistant Bacteria - WRAIR Discovery and Wound Program. The Army Medical Command also received DHP Congressional Special Interest (CSI) research funding focused on Peer-Reviewed Traumatic Brain Injury and Psychological Health Research. Because of the CSI annual structure, out-year funding is not programmed. For the Air Force, this PE funds applied research which seeks to promote ‘omic’-informed personalized medicine, advanced diagnostic technologies and occupational toxicology with an emphasis on targeted prevention, diagnosis, and treatment. The delivery of pro-active, evidence-based, personalized medicine will improve health in Warfighters and beneficiaries by providing care that is specific to the situation and patient, to include preventing disease or injury, early and accurate diagnosis, and selection of appropriate and effective treatment. Personalized medicine will reduce morbidity, mortality, mission impact of illness/injury, and healthcare costs while increasing health and wellness of the AF population and efficiency of the healthcare system. This applied research supports multiple focus areas, each of which represents an identified barrier/gap which must be addressed for successful implementation of ‘omic-informed personalized medicine. Focus areas for applied research include knowledge generation research; ethical legal and social issues/policy research; bioinformatics research; educational research; research for development of advanced genomic diagnostic system. For efforts supported by this program element, research will be pursued with the intent to support solutions that answer Air Force specific needs. During this process, the efforts of other government agencies in those areas will be assessed to avoid redundancy.

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Document Type: R2 Budgetary Justification
Publication Date: Oct 01, 2016
Source ID: 0602115HP_2_0130_PB_2016
Change Summary Explanation: FY 2014: Realignment from Defense Health Program, Research, Development, Test and Evaluation (DHP RDT&E), Program Element (PE) 0602115-Applied Biomedical Technology (-$1.793 million) to DHP RDT&E, PE 0605502-Small Business Innovation Research (SBIR) Program (+$1.793 million). FY 2014: Congressional Special Interest (CSI) Additions to DHP RDT&E, PE 0602115-Applied Biomedical Technology (+$15.000 million). FY 2015: Congressional Special Interest (CSI) Additions to DHP RDT&E, PE 0602115-Applied Biomedical Technology (+$25.303 million). FY2016: Realignment Global Health Security Agenda (GHSA) adjustment to DHP RDT&E, PE 0602115-Applied Biomedical Technology (+$3.150 million).
Service Agency Name: Defense Health Program

Applied Biomedical Technology

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