Restoring Cognitive Capability
Abstract
The Restoring Cognitive Capability program, building upon efforts initiated in the Enhancing Neuroplasticity program also budgeted in this PE and Project, will develop novel drugs to provide rapid therapy for neuropsychiatric disorders experienced by warfighters and veterans. Active duty military personnel face increased risk of acute and chronic neuropsychiatric dysfunction, limiting day-to-day function and return to duty. Current therapeutic approaches for many neuropsychiatric disorders (e.g., Post Traumatic Stress Disorder [PTSD], mood disorders, and substance abuse) rely on individual management with integrated psychiatric therapy and medication. However, most interventions approved for use in these conditions lack long-term efficacy, involve a logistical burden of treatment and/or carry a risk of serious adverse side effects. The Restoring Cognitive Capability program will develop and test novel drug chemotypes designed to functionally interact with neuronal receptor subtypes known to play a role in these neuropsychiatric conditions, with the aim of enabling fast-acting and effective alleviation of neuropsychiatric dysfunction with single or minimal doses.
Document Details
- Document Type
- Accomplishment
- Publication Date
- Oct 01, 2021
- Source ID
- 086bdd351efe81dc6a51bdc5e0c71c62