Coordinating nucleoporin condensation and nuclear pore complex assembly
Abstract
The nuclear pore complex (NPC) is among the most elaborate protein complexes in eukaryotes. While ribosomes and proteasomes are known to require dedicated assembly machinery, our understanding of NPC assembly is at a relatively early stage. Defects in NPC assembly or homeostasis are tied to movement disorders, including dystonia and amyotrophic lateral sclerosis (ALS), as well as aging, requiring a better understanding of these processes to enable therapeutic intervention. Here, we discuss recent progress in the understanding of NPC assembly and highlight how related defects in human disorders can shed light on NPC biogenesis. We propose that the condensation of phenylalanine‐glycine repeat nucleoporins needs to be carefully controlled during NPC assembly to prevent aberrant condensation, aggregation, or amyloid formation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 30, 2023
- Source ID
- 10.1002/1873-3468.14725
Entities
People
- Christian Schlieker
- Els F E Kuiper
- Sarah Prophet
Organizations
- Dutch Research Council
- Dystonia Medical Research Foundation
- European Molecular Biology Organization
- United States Department of Defense
- Yale School of Medicine
- Yale University