Flupirtine and diazepam combination terminates established status epilepticus: results in three rodent models

Abstract

Status epilepticus (SE) is a neurological emergency requiring rapid termination of seizures. New treatment choices are needed for benzodiazepine‐refractory SE or established SE (ESE). Previous studies have demonstrated that the potassium‐channel opener flupirtine terminates seizures in neonatal animals. However, its effectiveness in adult ESE has not been tested. We tested whether flupirtine alone or in combination with the benzodiazepine diazepam would terminate ESE in three animal models.

Document Details

Document Type
Pub Defense Publication
Publication Date
Nov 07, 2017
Source ID
10.1002/acn3.497

Entities

People

  • Jaideep Kapur
  • John Williamson
  • Marko S. Todorovic
  • Terry Zhang

Organizations

  • Congressionally Directed Medical Research Programs
  • National Institute of Neurological Disorders and Stroke
  • University of Virginia

Tags

Fields of Study

  • Medicine
  • Psychology

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