Visual spatial learning outcomes for clinical trials in neurofibromatosis type 1
Abstract
Cognitive problems are common in children with neurofibromatosis type 1, representing a significant source of lifelong morbidity. Assessment of cognitive function has been challenging in the setting of clinical trials. Spatial learning deficits may be an important target for cognitive interventions. We leveraged a large, international cognitive study in affected children with NF1 treated with lovastatin to assess spatial learning using the “Arena Maze”, a portable, computerized task that allows for retesting in the same environment. As with the parent study, spatial learning assessed with this task did not improve with lovastatin treatment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 01, 2020
- Source ID
- 10.1002/acn3.50976
Entities
People
- Celiane Rey-Casserly
- Gary R. Cutter
- Jonathan M Payne
- Karin S Walsh
- Kathryn North
- Nicole J Ullrich
- Roger Packer
- The Nf Clinical Trials Consortium
Organizations
- Boston Children's Hospital
- Children's National Hospital
- Royal Children's Hospital
- United States Army Medical Research and Development Command
- University of Alabama
- University of Melbourne