Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury
Abstract
Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long‐term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE). To date, preclinical studies largely have focused on the immediate aftermath of mTBI, with no literature on the lifelong consequences of mTBI in these models. This study provides the first account of lifelong neurobehavioral and histological consequences of repetitive mTBI providing unique insight into the constellation of evolving and ongoing pathologies with late survival.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 14, 2017
- Source ID
- 10.1002/acn3.510
Entities
People
- Benoit C. Mouzon
- Christopher M. Acker
- Corbin Bachmeier
- Daniel Paris
- Fiona Crawford
- Ghania Ait‐ghezala
- Gogce Crynen
- Joseph O. Ojo
- Michael Mullan
- Peter Davies
- Scott Ferguson
- William Stewart
Organizations
- James A. Haley Veterans' Hospital
- National Institutes of Health
- Roskamp Institute
- The Feinstein Institute for Medical Research
- The Open University
- United States Department of Defense
- United States Department of Veterans Affairs
- University of Glasgow