Inhibition of Ras GTPases prevents Collagen‐Induced Arthritis by Reducing the Generation of Pathogenic CD4+ T Cells and the Hyposialylation of Autoantibodies
Abstract
RasGTPases are master regulators of multiple intracellular signaling cascades. Perturbation of this pathway has been implicated in the pathogenesis of rheumatoid arthritis (RA). In this study we aimed to define the therapeutic potential of a novel RasGTPases inhibitor, farnesylthiosalicylate (FTS), in the preclinical mouse model of collagen‐induced arthritis (CIA) and better delineate its immunomodulatory effects both ex vivo and in the mouse.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2020
- Source ID
- 10.1002/acr2.11169
Entities
People
- Einav Vax
- Galit Elad‐sfadia
- Iris Barshack
- Itamar Goldstein
- Morad Zayoud
- Ronit Pinkas‐kramarski
Organizations
- Rambam Health Care Campus
- Tel Aviv University
- United States Army Medical Research and Development Command