A Pilot Analysis of Genome‐Wide DNA Methylation Patterns in Mouse Cartilage Reveals Overlapping Epigenetic Signatures of Aging and Osteoarthritis
Abstract
Cartilage epigenetic changes are strongly associated with human osteoarthritis (OA). However, the influence of individual environmental OA risk factors on these epigenetic patterns has not been determined; herein we characterize cartilage DNA methylation patterns associated with aging and OA in a mouse model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 17, 2022
- Source ID
- 10.1002/acr2.11506
Entities
People
- Cassandra Sturdy
- Christopher M. Dunn
- Emily Nguyen
- Emmaline Prinz
- Leoni Schlupp
- Matlock Jeffries
- Vladislav Izda
Organizations
- Congressionally Directed Medical Research Programs
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute of General Medical Sciences
- Oklahoma Medical Research Foundation
- University of Oklahoma Health Sciences Center