A semi‐adaptive control approach to closed‐loop medication infusion
Abstract
This paper presents a semi‐adaptive control approach to closed‐loop medication infusion problems. The rationale underlying this approach is to design a controller that can adapt model parameters with a large impact on the model's fidelity while fixing the remaining parameters at nominal values. In this paper, a control‐oriented model for this purpose is derived via system identification and sensitivity analysis of a low‐order model capturing the direct dose‐response relationship Using the model thus derived, a model‐reference adaptive controller and a composite adaptive controller are designed and compared with each other. In‐silico simulation results using remifentanil's effect on respiratory rate as an example indicate that both controllers can regulate the output at commanded set points. Copyright © 2016 John Wiley & Sons, Ltd.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 30, 2016
- Source ID
- 10.1002/acs.2696
Entities
People
- Chang‐sei Kim
- Guy A. Dumont
- J. Mark Ansermino
- Jin‐oh Hahn
- Xin Jin
Organizations
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council
- Office of Naval Research
- University of British Columbia
- University of Maryland