Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery
Abstract
Coassembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro. Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein‐mimetic peptide, localize at plaque sites in low density lipoprotein receptor knockout (LDLR KO) mice with or without the encapsulated molecule, while nanofibers displaying a scrambled, nontargeting peptide sequence do not demonstrate comparable binding. These results show that nanofibers functionalized with apolipoprotein‐mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 12, 2018
- Source ID
- 10.1002/adbi.201700123
Entities
People
- Charles M. Rubert Pérez
- Erica B Peters
- Mazen S. Albaghdadi
- Melina R. Kibbe
- Miranda M. So
- Neel A. Mansukhani
- Samuel I. Stupp
- Zheng Wang
Organizations
- American Medical Association Foundation
- Army Research Office
- National Center for Advancing Translational Sciences
- National Heart, Lung, and Blood Institute
- National Science Foundation
- Northwestern Memorial Foundation
- Northwestern University
- United States Army Medical Research and Development Command
- University of North Carolina at Chapel Hill