Photoresponsive Protein–Graphene–Protein Hybrid Capsules with Dual Targeted Heat‐Triggered Drug Delivery Approach for Enhanced Tumor Therapy
Abstract
A novel photo‐responsive protein–graphene–protein (PGP) capsule that doubles as a photothermal agent with core/shell structure is constructed by anchoring reduced graphene oxide nanosheets on one‐component protein (lactoferrin) shell through a double emulsion method. PGP capsules can transport fully concealed hydrophilic anticancer cargo, doxorubicin (Dox), with a large payload (9.43 μmol g‐1) to be later unloaded in a burst‐like manner by photo‐actuation triggered by near‐infrared irradiation. Being biocompatible yet with a high cancer cell targeting efficiency, PGP capsules have successfully eradicated subcutaneous tumors in 10 d following a single 5 min NIR irradiation without distal damage. Besides, the photochemothermal therapy of PGP capsules eradicates tumor cells not only in the light‐treating area but also widely light‐omitted tumor cells, overcoming the tumor recurrence due to efficient cell killing efficacy. These results demonstrate that the PGP capsule is a potential new drug delivery platform for local‐targeting, on‐demand, photoresponsive, combined chemotherapy/hyperthermia for tumor treatment and other biomedical applications.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 02, 2014
- Source ID
- 10.1002/adfm.201400080
Entities
People
- Bang‐jie Liao
- I‐wei Chen
- Ren‐hong Fang
- San‐yuan Chen
- Shang‐hsiu Hu
- Yu‐wei Chen
Organizations
- Ministry of Education of the Republic of Korea
- National Chiao Tung University
- National Science and Technology Council
- National Tsing Hua University
- United States Army Medical Research and Development Command
- University of Pennsylvania