Development and Translation of PEDOT:PSS Microelectrodes for Intraoperative Monitoring
Abstract
Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of neural mechanisms and organization. However, increasing clinical electrodes' signal‐to‐noise and spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The electrochemical properties of poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based interfaces surpass those of current clinical electrocorticography electrodes. Here, robust fabrication process of PEDOT:PSS microelectrode arrays is demonstrated for safe and high fidelity intraoperative monitoring of human brain. PEDOT:PSS microelectrodes measure significant differential neural modulation under various clinically relevant conditions. This study reports the first evoked (stimulus‐locked) cognitive activity with changes in amplitude across pial surface distances as small as 400 µm, potentially enabling basic neurophysiology studies at the scale of neural micro‐circuitry.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 12, 2017
- Source ID
- 10.1002/adfm.201700232
Entities
People
- Atsunori Tanaka
- Bob S. Carter
- Daniel Cleary
- David Barba
- Eric Halgren
- Erik Kaestner
- Garth Rees Cosgrove
- George G. Malliaras
- Ilke Uguz
- John Hermiz
- Jospeh Snider
- Mehran Ganji
- Mila Halgren
- Nick Rogers
- Sang Heon Lee
- Shadi A Dayeh
- Sydney S. Cash
- Vikash Gilja
Organizations
- Brigham and Women's Hospital
- Massachusetts General Hospital
- National Science Foundation
- Office of Naval Research
- University of California
- University of California, San Diego