Remote‐Loaded Platelet Vesicles for Disease‐Targeted Delivery of Therapeutics
Abstract
The recent emergence of biomimetic nanotechnology has facilitated the development of next‐generation nanodelivery systems capable of enhanced biointerfacing. In particular, the direct use of natural cell membranes can enable multivalent targeting functionalities. Herein, this study reports on the remote loading of small molecule therapeutics into cholesterol‐enriched platelet membrane‐derived vesicles for disease‐targeted delivery. Using this approach, high loading yields for two model drugs, doxorubicin and vancomycin, are achieved. Leveraging the surface markers found on platelet membranes, the resultant nanoformulations demonstrate natural affinity toward both breast cancer cells and methicillin‐resistant Staphylococcus aureus. In vivo, this translates to improved disease targeting, increasing the potency of the encapsulated drug payloads compared with free drugs and the corresponding nontargeted nanoformulations. Overall, this work demonstrates that the remote loading of drugs into functional platelet membrane‐derived vesicles is a facile means of fabricating targeted nanoformulations, an approach that can be easily generalized to other cell types in the future.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 19, 2018
- Source ID
- 10.1002/adfm.201801032
Entities
People
- Diana Dehaini
- Jia Zhuang
- Liangfang Zhang
- Man Ying
- Mengchun Chen
- Ronnie H Fang
- Silun Gu
- Weiwei Gao
- Weiyue Lu
- Xiaoli Wei
- Xinxin Zhang
- Yao Jiang
- Yue Zhang
Organizations
- Defense Threat Reduction Agency
- Fudan University
- National Institutes of Health
- University of California, San Diego