Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling
Abstract
Magnetic nanoparticles have garnered sustained research interest for their promise in biomedical applications including diagnostic imaging, triggered drug release, cancer hyperthermia, and neural stimulation. Many of these applications make use of heat dissipation by ferrite nanoparticles under alternating magnetic fields, with these fields acting as an externally administered stimulus that is either present or absent, toggling heat dissipation on and off. Here, an extension of this concept, magnetothermal multiplexing is demonstrated, in which exposure to alternating magnetic fields of differing amplitude and frequency can result in selective and independent heating of magnetic nanoparticle ensembles. The differing magnetic coercivity of these particles, empirically characterized by a custom high amplitude alternating current magnetometer, informs the systematic selection of a multiplexed material system. This work culminates in a demonstration of magnetothermal multiplexing for selective remote control of cellular signaling in vitro.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 10, 2020
- Source ID
- 10.1002/adfm.202000577
Entities
People
- Colin Marcus
- Danijela Gregurec
- David C. Bono
- Dekel Rosenfeld
- Georgios Varnavides
- Junsang Moon
- Michael G. Christiansen
- Polina Anikeeva
- Po‐han Chiang
- Seongjun Park
- Siyuan Rao
Organizations
- Defense Advanced Research Projects Agency
- ETH Zurich
- KAIST
- Massachusetts Institute of Technology
- National Chiao Tung University
- National Institutes of Health
- National Science Foundation