Dual Polymerizations: Untapped Potential for Biomaterials
Abstract
Block copolymers with unique architectures and those that can self‐assemble into supramolecular structures are used in medicine as biomaterial scaffolds and delivery vehicles for cells, therapeutics, and imaging agents. To date, much of the work relies on controlling polymer behavior by varying the monomer side chains to add functionality and tune hydrophobicity. Although varying the side chains is an efficient strategy to control polymer behavior, changing the polymer backbone can also be a powerful approach to modulate polymer self‐assembly, rigidity, reactivity, and biodegradability for biomedical applications. There are many developments in the syntheses of polymers with segmented backbones, but these developments are not widely adopted as strategies to address the unique constraints and requirements of polymers for biomedical applications. This review highlights dual polymerization strategies for the synthesis of backbone‐segmented block copolymers to facilitate their adoption for biomedical applications.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 21, 2018
- Source ID
- 10.1002/adhm.201800861
Entities
People
- Alex N. Prossnitz
- Andrew J. Boydston
- Daniel C Lee
- Robert J. Lamm
- Suzie H. Pun
Organizations
- National Institutes of Health
- National Science Foundation
- United States Department of Defense
- University of Washington