Two‐Photon In Vivo Imaging with Porous Silicon Nanoparticles
Abstract
A major obstacle in luminescence imaging is the limited penetration of visible light into tissues and interference associated with light scattering and autofluorescence. Near‐infrared (NIR) emitters that can also be excited with NIR radiation via two‐photon processes can mitigate these factors somewhat because they operate at wavelengths of 650–1000 nm where tissues are more transparent, light scattering is less efficient, and endogenous fluorophores are less likely to absorb. This study presents photolytically stable, NIR photoluminescent, porous silicon nanoparticles with a relatively high two‐photon‐absorption cross‐section and a large emission quantum yield. Their ability to be targeted to tumor tissues in vivo using the iRGD targeting peptide is demonstrated, and the distribution of the nanoparticles with high spatial resolution is visualized.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 21, 2017
- Source ID
- 10.1002/adma.201703309
Entities
People
- Dokyoung Kim
- Hye Gun Ryu
- Jinmyoung Joo
- Jinyoung Kang
- Jonathan M Zuidema
- Junyang Jung
- Ki Hean Kim
- Kyo Han Ahn
- Michael Sailor
- Muwoong Kim
- Taejun Wang
- Youngbuhm Huh
Organizations
- Defense Advanced Research Projects Agency
- Kyung Hee University
- Ministry of Education of the Republic of Korea
- Ministry of Education, Science and Technology
- Ministry of Health and Welfare
- National Research Foundation of Korea
- National Science Foundation
- Pohang University of Science and Technology
- University of California, San Diego
- University of Ulsan College of Medicine
- Yusuf Hamied Department of Chemistry