SupraCells: Living Mammalian Cells Protected within Functional Modular Nanoparticle‐Based Exoskeletons
Abstract
Creating a synthetic exoskeleton from abiotic materials to protect delicate mammalian cells and impart them with new functionalities could revolutionize fields like cell‐based sensing and create diverse new cellular phenotypes. Herein, the concept of “SupraCells,” which are living mammalian cells encapsulated and protected within functional modular nanoparticle‐based exoskeletons, is introduced. Exoskeletons are generated within seconds through immediate interparticle and cell/particle complexation that abolishes the macropinocytotic and endocytotic nanoparticle internalization pathways that occur without complexation. SupraCell formation is shown to be generalizable to wide classes of nanoparticles and various types of cells. It induces a spore‐like state, wherein cells do not replicate or spread on surfaces but are endowed with extremophile properties, for example, resistance to osmotic stress, reactive oxygen species, pH, and UV exposure, along with abiotic properties like magnetism, conductivity, and multifluorescence. Upon decomplexation cells return to their normal replicative states. SupraCells represent a new class of living hybrid materials with a broad range of functionalities.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 29, 2019
- Source ID
- 10.1002/adma.201900545
Entities
People
- Achraf Noureddine
- Andreas Zimpel
- C. Jeffrey Brinker
- Frank Caruso
- Jacob Ongudi Agola
- Jimin Guo
- Jin Shang
- Jonas G Croissant
- Shahrouz Amini
- Stefan Wuttke
- Wei Zhu
- Yi Ju
Organizations
- Air Force Office of Scientific Research
- Australian Research Council
- City University of Hong Kong
- Ludwig-Maximilians-Universität München
- Max Planck Institute for Colloids and Interfaces
- South China University of Technology
- United States Department of Energy
- University of Melbourne
- University of New Mexico