Physical Disruption of Solid Tumors by Immunostimulatory Microrobots Enhances Antitumor Immunity
Abstract
The combination of immunotherapy with other forms of treatment is an emerging strategy for boosting antitumor responses. By combining multiple modes of action, these combinatorial therapies can improve clinical outcomes through unique synergisms. Here, a microrobot‐based strategy that integrates tumor tissue disruption with biological stimulation is shown for cancer immunotherapy. The microrobot is fabricated by loading bacterial outer membrane vesicles onto a self‐propelling micromotor, which can react with water to generate a propulsion force. When administered intratumorally to a solid tumor, the disruption of the local tumor tissue coupled with the delivery of an immunostimulatory payload leads to complete tumor regression. Additionally, treatment of the primary tumor results in the simultaneous education of the host immune system, enabling it to control the growth of distant tumors. Overall, this work introduces a distinct application of microrobots in cancer immunotherapy and offers an attractive strategy for amplifying cancer treatment efficacy when combined with conventional therapies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 11, 2021
- Source ID
- 10.1002/adma.202103505
Entities
People
- Berta Esteban‐fernandez De Avila
- Christian J. Ventura
- Crystal Xiao
- Emil Karshalev
- Hua Gong
- Jiarong Zhou
- Joseph Wang
- Liangfang Zhang
- Nishta Krishnan
- Qiangzhe Zhang
- Rodolfo Mundaca‐uribe
- Ronnie H Fang
- Weiwei Gao
Organizations
- Defense Threat Reduction Agency
- National Institutes of Health
- University of California, San Diego