Monte Carlo Simulations Reveal New Design Principles for Efficient Nanoradiosensitizers Based on Nanoscale Metal–Organic Frameworks
Abstract
Nanoscale metal–organic frameworks (nMOFs) have recently been shown to provide better radiosensitization than solid nanoparticles (NPs) when excited with X‐rays. Here, a Monte Carlo simulation of different radiosensitization effects by NPs and nMOFs using a lattice model consisting of 3D arrays of nanoscale secondary building units (SBUs) is reported. The simulation results reveal that lattices outperform solid NPs regardless of radiation sources or particle sizes via enhanced scatterings of photons and electrons within the lattices. Optimum dose enhancement can be achieved by tuning SBU size and inter‐SBU distance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 25, 2021
- Source ID
- 10.1002/adma.202104249
Entities
People
- Jianming Mao
- Kaiyuan Ni
- Taokun Luo
- Wenbin Lin
- Ziwan Xu
Organizations
- National Cancer Institute
- United States Department of Defense
- University of Chicago