Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors
Abstract
Biofouling on the surface of implanted medical devices and biosensors severely hinders device functionality and drastically shortens device lifetime. Poly(ethylene glycol) and zwitterionic polymers are currently considered “gold‐standard” device coatings to reduce biofouling. To discover novel anti‐biofouling materials, a combinatorial library of polyacrylamide‐based copolymer hydrogels is created, and their ability is screened to prevent fouling from serum and platelet‐rich plasma in a high‐throughput parallel assay. It is found that certain nonintuitive copolymer compositions exhibit superior anti‐biofouling properties over current gold‐standard materials, and machine learning is used to identify key molecular features underpinning their performance. For validation, the surfaces of electrochemical biosensors are coated with hydrogels and their anti‐biofouling performance in vitro and in vivo in rodent models is evaluated. The copolymer hydrogels preserve device function and enable continuous measurements of a small‐molecule drug in vivo better than gold‐standard coatings. The novel methodology described enables the discovery of anti‐biofouling materials that can extend the lifetime of real‐time in vivo sensing devices.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 12, 2022
- Source ID
- 10.1002/adma.202109764
Entities
People
- Abigail K. Grosskopf
- Caitlin Maikawa
- Dmitry Yu. Zubarev
- Doreen Chan
- Eneko Axpe
- Eric A Appel
- Hyongsok Soh
- Joseph L Mann
- Jun‐chau Chien
- Louis Blankemeier
- Samuel W. Baker
- Sarath Swaminathan
- Victoria A. Piunova
Organizations
- Air Force Office of Scientific Research
- Chan Zuckerberg Biohub
- International Business Machines Corporation (Armonk, NY)
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Science Foundation
- Stanford University
- United States Department of Defense