Metasurfaces‐Driven Hyperspectral Imaging via Multiplexed Plasmonic Resonance Energy Transfer
Abstract
Obtaining single–molecular–level fingerprints of biomolecules and electron–transfer dynamic imaging in living cells are critically demanded in postgenomic life sciences and medicine. However, the possible solution called plasmonic resonance energy transfer (PRET) spectroscopy remains challenging due to the fixed scattering spectrum of a plasmonic nanoparticle and limited multiplexing. Here, multiplexed metasurfaces‐driven PRET hyperspectral imaging, to probe biological light–matter interactions, is reported. Pixelated metasurfaces with engineered scattering spectra are first designed over the entire visible range by the precision nanoengineering of gap plasmon and grating effects of metasurface clusters. Pixelated metasurfaces are created and their full dark‐field coloration is optically characterized with visible color palettes and high‐resolution color printings of the art pieces. Furthermore, three different biomolecules (i.e., chlorophyll a, chlorophyll b, and cytochrome c) are applied on metasurfaces for color palettes to obtain selective molecular fingerprint imaging due to the unique biological light–matter interactions with application‐specific biomedical metasurfaces. This metasurface‐driven PRET hyperspectral imaging will open up a new path for multiplexed real‐time molecular sensing and imaging methods.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 11, 2023
- Source ID
- 10.1002/adma.202300229
Entities
People
- Aleksandr Barulin
- Hongyoon Kim
- Inhee Choi
- Inki Kim
- Joohoon Kim
- Junsuk Rho
- Luke P Lee
- Seonghyeon Eom
- Seungyeon Han
- Yangkyu Kim
Organizations
- Air Force Office of Scientific Research
- Harvard Medical School
- National Research Foundation of Korea
- POSCO
- Pohang University of Science and Technology
- Samsung Group
- Sungkyunkwan University
- University of California, Berkeley
- University of Seoul