Graphene Chemeo‐Phononics for Biosensor Applications: An Interfacial Raman Transducer
Abstract
Leveraging the phononic sensitivity and scalability of nano‐biointerfaces has accelerated the growth of unique and versatile biosensors. Graphene has the properties of a near‐ideal signal transducer, due to the strong coupling between its interfacial and phononic properties. This enables sensitive yet quick detection of surface interactions on graphene via Raman spectral analysis. The Raman‐active vibrational bands of graphene are demonstrated to be sensitive to structural, electrical, and interfacial modifications. This sensitivity is attributed to graphene's electron–phonon coupling and high quantum capacitance. The fundamental understanding of graphene phonons is crucial for developing reliable platforms for disease and infectious agent detection. This review provides a mechanistic explanation of these phenomena at the interface between graphene and various biosystems (including cancerous, bacterial, viral, and biophysical specimens) to set the foundation for next‐generation chemeo‐phononic medical devices.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 13, 2022
- Source ID
- 10.1002/admi.202200773
Entities
People
- Bijentimala Keisham
- Sheldon Cotts
- Sungjoon Kim
- Vikas Berry
Organizations
- Office of Naval Research
- University of Chicago
- University of Illinois at Chicago