Extrusion and Microfluidic‐Based Bioprinting to Fabricate Biomimetic Tissues and Organs
Abstract
Next generation engineered tissue constructs with complex and ordered architectures aim to better mimic the native tissue structures, largely due to advances in 3D bioprinting techniques. Extrusion bioprinting has drawn tremendous attention due to its widespread availability, cost‐effectiveness, simplicity, and its facile and rapid processing. However, poor printing resolution and low speed have limited its fidelity and clinical implementation. To circumvent the downsides associated with extrusion printing, microfluidic technologies are increasingly being implemented in 3D bioprinting for engineering living constructs. These technologies enable biofabrication of heterogeneous biomimetic structures made of different types of cells, biomaterials, and biomolecules. Microfluiding bioprinting technology enables highly controlled fabrication of 3D constructs in high resolutions and it has been shown to be useful for building tubular structures and vascularized constructs, which may promote the survival and integration of implanted engineered tissues. Although this field is currently in its early development and the number of bioprinted implants is limited, it is envisioned that it will have a major impact on the production of customized clinical‐grade tissue constructs. Further studies are, however, needed to fully demonstrate the effectiveness of the technology in the lab and its translation to the clinic.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 26, 2020
- Source ID
- 10.1002/admt.201901044
Entities
People
- Ali Khademhosseini
- Ehsan Toyserkani
- Einollah Sarikhani
- Elham Davoodi
- Hossein Montazerian
- Konrad Walus
- Marco Costantini
- Mohammad Mofidfar
- Nureddin Ashammakhi
- Samad Ahadian
- Stephanie Michelle Willerth
- Wojciech Swieszkowski
Organizations
- Institute of Physical Chemistry, Polish Academy of Sciences
- Michael Smith Foundation for Health Research
- National Centre for Research and Development in Poland
- National Institutes of Health
- Natural Sciences and Engineering Research Council
- United States Department of Defense
- University of British Columbia
- University of California
- University of California, Los Angeles
- University of Southern California
- University of Victoria
- University of Waterloo
- Warsaw University of Technology