Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
Abstract
Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle arrest after experiencing inherent or environmental stresses. Although cellular senescence is essential in several physiological events, it plays a detrimental role in a large array of age‐related pathologies. Recent biomedical advances in specifically targeting senescent cells to improve healthy aging, or alternatively, postpone natural aging and age‐related diseases, a strategy termed senotherapy, have attracted substantial interest in both scientific and medical communities. Challenges for aging research are highlighted and potential avenues that can be leveraged for therapeutic interventions to control aging and age‐related disorders in the current era of precision medicine.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 19, 2020
- Source ID
- 10.1002/advs.202002611
Entities
People
- James L. Kirkland
- Jing Jiang
- Shuling Song
- Tamara Tchkonia
- Y Sun
Organizations
- Binzhou Medical University
- Mayo Clinic
- National Institutes of Health
- National Natural Science Foundation of China
- Shanghai Municipal Science and Technology Commission
- United States Department of Defense
- University of Chinese Academy of Sciences
- University of Washington