The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

Abstract

Inflammation has emerged as an important factor in disease progression in human and transgenic models of amyotrophic lateral sclerosis (ALS). Recent studies demonstrate that the prostaglandin E2 EP2 receptor is a major regulator of inflammatory oxidative injury in innate immunity. We tested whether EP2 signaling participated in disease pathogenesis in the G93A superoxide dismutase (SOD) model of familial ALS.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Sep 28, 2008
• Source ID: 10.1002/ana.21437

Entities

People

• Ju Shi
• Katrin Andreasson
• Ludmila Lokteva
• Qian Wang
• Richard M. Breyer
• Thomas J. Montine
• Xibin Liang

Organizations

• American Federation for Aging Research
• Muscular Dystrophy Association
• National Institutes of Health
• United States Department of Defense

Tags

Fields of Study

• Medicine

Readers

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