Pediatric super‐refractory status epilepticus treated with allopregnanolone
Abstract
Super‐refractory status epilepticus is a life‐threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic γ‐aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors. Here we describe the use of allopregnanolone in 2 pediatric patients with super‐refractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus. This is the first report of allopregnanolone use to treat status epilepticus in children. Ann Neurol 2014;76:911–915
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 11, 2014
- Source ID
- 10.1002/ana.24295
Entities
People
- Celia Chang
- Craig M. Smith
- Eileen Broomall
- Joanne E. Natale
- Joshua R. Goldstein
- Mark S. Wainwright
- Michael A. Rogawski
- Michele Grimason
- Stephen Kanes
Organizations
- Congressionally Directed Medical Research Programs
- National Institute of Neurological Disorders and Stroke
- Northwestern University
- University of California, Davis