Seed‐competent high‐molecular‐weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients
Abstract
Cerebrospinal fluid (CSF) tau is an excellent surrogate marker for assessing neuropathological changes that occur in Alzheimer's disease (AD) patients. However, whether the elevated tau in AD CSF is just a marker of neurodegeneration or, in fact, a part of the disease process is uncertain. Moreover, it is unknown how CSF tau relates to the recently described soluble high‐molecular‐weight (HMW) species that is found in the postmortem AD brain and can be taken up by neurons and seed aggregates.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 03, 2016
- Source ID
- 10.1002/ana.24716
Entities
People
- Alexis E. Sherman
- Allyson D. Roe
- Ana T. Trisini Lipsanopoulos
- Bradley T. Hyman
- Caitlin Commins
- Chloe K. Nobuhara
- Clemens R. Scherzer
- Elaine R. Peskind
- Ge Li
- George A. Carlson
- Isabel Costantino
- Matthew P. Frosch
- Murray A. Raskind
- Rose Pitstick
- Samantha B. Nicholls
- Sarah L. Devos
- Shuko Takeda
- Susanne Wegmann
- Thomas J. Montine
- Zhanyun Fan
Organizations
- Brigham and Women's Hospital
- Harvard Medical School
- McLaughlin Research Institute
- National Institutes of Health
- United States Department of Veterans Affairs
- University of Washington