The melanoma‐linked “redhead” MC1R influences dopaminergic neuron survival
Abstract
Individuals with Parkinson disease are more likely to develop melanoma, and melanoma patients are reciprocally at higher risk of developing Parkinson disease. Melanoma is strongly tied to red hair/fair skin, a phenotype of loss‐of‐function polymorphisms in the MC1R (melanocortin 1 receptor) gene. Loss‐of‐function variants of MC1R have also been linked to increased risk of Parkinson disease. The present study is to investigate the role of MC1R in dopaminergic neurons in vivo.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 23, 2017
- Source ID
- 10.1002/ana.24852
Entities
People
- Bailiu Ya
- Charles R. Vanderburg
- David E. Fisher
- Fuxing Zuo
- Hongxiang Chen
- Hui Li
- Katey Robinson
- Michael A Schwarzschild
- Michael Maguire
- Robert Logan
- Waijiao Cai
- Xiqun Chen
- Yang Yu
- Yinsheng Wang
Organizations
- Harvard NeuroDiscovery Center
- Massachusetts General Hospital
- National Institutes of Health
- National Natural Science Foundation of China
- The Michael J. Fox Foundation
- Tongji University
- University of California, Riverside