Network Localization of Alien Limb in Patients with Corticobasal Syndrome

Abstract

Perirolandic atrophy occurs in corticobasal syndrome (CBS) but is not specific versus progressive supranuclear palsy (PSP). There is heterogeneity in the locations of atrophy outside the perirolandic cortex and it remains unknown why atrophy in different locations would cause the same CBS‐specific symptoms. In prior work, we used a wiring diagram of the brain called the human connectome to localize lesion‐induced disorders to symptom‐specific brain networks. Here, we use a similar technique termed “atrophy network mapping” to localize single‐subject atrophy maps to symptom‐specific brain networks.

Document Details

Document Type
Pub Defense Publication
Publication Date
Oct 02, 2020
Source ID
10.1002/ana.25901

Entities

People

  • Aaron M. Tetreault
  • Anja Schneider
  • Bryan J Neth
  • Daniel O. Claassen
  • For The 4 Repeat Tau Neuroimaging Initiative
  • Franziska Albrecht
  • Janine Diehl‐schmid
  • Jonathan Graff-Radford
  • Kalen J. Petersen
  • Klaus Fliessbach
  • Markus Otto
  • Matthias L. Schroeter
  • Matthis Synofzik
  • Richard Ryan Darby
  • Tony Phan

Organizations

  • Alzheimer's Association
  • BrightFocus Foundation
  • Leipzig University
  • Mayo Clinic
  • Technical University of Munich
  • United States Department of Defense
  • University of Bonn
  • University of Tübingen
  • Universitätsmedizin Göttingen
  • Vanderbilt University

Tags

Fields of Study

  • Medicine
  • Psychology

Readers

  • Neuroscience
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.