Bright, “Clickable” Porphyrins for the Visualization of Oxygenation under Ambient Light
Abstract
A new group of “clickable” and brightly emissive metalloporphyrins has been developed for the visualization of oxygenation under ambient light with the naked eye. These alkynyl‐terminated compounds permit the rapid and facile synthesis of oxygen‐sensing dendrimers through azide–alkyne click chemistry. With absorption maxima overlapping with the wavelengths of common commercial laser sources, they are readily applicable to biomedical imaging of tissue oxygenation. An efficient synthetic methodology, featuring the stable trimethylacetyl (pivaloyl) protecting group, is described for their preparation. A paint‐on liquid bandage containing a new, click‐synthesized porphyrin dendrimer has been used to map oxygenation across an ex vivo porcine skin burn model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 29, 2015
- Source ID
- 10.1002/ange.201506847
Entities
People
- Alexander J. Nichols
- Conor L Evans
- Emmanuel Roussakis
- Nicholas H. Nowell
- Zongxi Li
Organizations
- Air Force Office of Scientific Research
- National Institutes of Health
- National Science Foundation