A Membrane‐Intercalating Conjugated Oligoelectrolyte with High‐Efficiency Photodynamic Antimicrobial Activity
Abstract
A membrane‐intercalating conjugated oligoelectrolyte (COE), PTTP, was designed and synthesized with the goal of providing red‐shifted absorption spectra relative to previously synthesized COE analogs. Specifically, electron‐rich and electron‐poor subunits were introduced in the conjugated backbone to modulate the band gap. PTTP exhibits maxima of absorption at 507 nm and of emission at 725 nm. PTTP can also efficiently function to generate singlet oxygen in situ (ΦΔ≈20 %) and has appropriate topology and dimensions to interact with lipid membranes. The resulting rapid membrane insertion and sensitizing ability provide PTTP with a highly efficient antibacterial capability under a low light dose (0.6 J cm−2) toward Gram‐negative bacteria E. coli, making it a remarkably efficient optically mediated antimicrobial agent.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 28, 2017
- Source ID
- 10.1002/ange.201701146
Entities
People
- Alexander Mikhailovsky
- Bing Wang
- Guillermo C. Bazan
- Mingxun Wang
- Shu Wang
Organizations
- Army Research Office
- National Science Foundation