Cellular‐ and Subcellular‐Targeted Delivery Using a Simple All‐in‐One Polymeric Nanoassembly
Abstract
Nanocarrier‐mediated drug delivery is a promising strategy to maximize the power of chemotherapy and minimize side effects. However, current approaches show insufficient drug‐loading capacity and inefficient drug release, and require complex modification processes. Attempts to enhance one of these features often compromise other merits. We describe here a block copolymer assembly system that combines desirable characteristics. The design of self‐immolative and crosslinkable hydrophobic moieties offer stable and high encapsulation. Redox‐triggerable polymer self‐immolation promotes drug release by switching the hydrophobic core into completely hydrophilic chains. The reactive amine handles, presented on their surface, allow “plug to direct” modification with targeting ligands. Functionalized nanoassemblies have been programmed to target specific subcellular compartments. The simplicity, versatility, and efficacy of the system open up possibilities for an all‐in‐one delivery system.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 23, 2020
- Source ID
- 10.1002/ange.202008272
Entities
People
- Jiaming Zhuang
- Jingjing Gao
- Kingshuk Dutta
- Sankaran Thayumanavan
Organizations
- Army Research Office
- National Institute of General Medical Sciences
- University of Massachusetts