Reconfigurable Two‐Dimensional DNA Lattices: Static and Dynamic Angle Control
Abstract
Branched DNA motifs serve as the basic construction elements for all synthetic DNA nanostructures. However, precise control of branching orientation remains a key challenge to further heighten the overall structural order. In this study, we use two strategies to control the branching orientation. The first one is based on immobile Holliday junctions which employ specific nucleotide sequences at the branch points which dictate their orientation. The second strategy is to use angle‐enforcing struts to fix the branching orientation with flexible spacers at the branch points. We have also demonstrated that the branching orientation control can be achieved dynamically, either by canonical Watson–Crick base pairing or non‐canonical nucleobase interactions (e.g., i‐motif and G‐quadruplex). With precise angle control and feedback from the chemical environment, these results will enable novel DNA nanomechanical sensing devices, and precisely‐ordered three‐dimensional architectures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 05, 2021
- Source ID
- 10.1002/ange.202112487
Entities
People
- Bryan Wei
- Chengxian Wu
- Chunyu Chen
- Nadrian C. Seeman
- Ruojie Sha
- Simon Vecchioni
- Tianqing Zhang
- Wen Wang
- Yoel P. Ohayon
Organizations
- Army Research Office
- Gordon and Betty Moore Foundation
- National Institute of General Medical Sciences
- National Natural Science Foundation of China
- National Science Foundation
- New York University
- Office of Naval Research
- United States Department of Energy