A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

Abstract

Within a total residence time of 9 min, the sodium salt of ciprofloxacin was prepared from simple building blocks via a linear sequence of six chemical reactions in five flow reactors. Sequential offline acidifications and filtrations afforded ciprofloxacin and ciprofloxacin hydrochloride. The overall yield of the eight‐step sequence was 60 %. No separation of intermediates was required throughout the synthesis when a single acylation reaction was applied to remove the main byproduct, dimethylamine.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jun 20, 2017
Source ID
10.1002/anie.201703812

Entities

People

  • Chunhui Dai
  • Hongkun Lin
  • Klavs F. Jensen
  • Timothy F. Jamison

Organizations

  • Defense Advanced Research Projects Agency
  • Massachusetts Institute of Technology

Tags

Fields of Study

  • Chemistry

Readers

  • Adaptive Control and Estimation with Uncertainty in Dynamic Systems.
  • Analytical Chemistry
  • Military/Explosive Ordnance Disposal (EOD) Technology