An Auto‐Inductive Cascade for the Optical Sensing of Thiols in Aqueous Media: Application in the Detection of a VX Nerve Agent Mimic
Abstract
A new auto‐inductive protocol employs a Meldrum's‐acid‐based conjugate acceptor (1) as a latent source of thiol for signal amplification, as well as optical detection of thiols. The auto‐induction is initiated by a thiol‐disulfide exchange that leads to the generation of β‐mercaptoethanol, which in turn decouples the conjugate acceptor to release more thiols, resulting in a self‐propagating cycle that continues until all the conjugate acceptor is consumed. Using 1 in a two‐step integrated protocol yields a rapid, sensitive, and precise diagnostic assay for the ultratrace quantitation of a thiophosphate nerve agent surrogate.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 03, 2017
- Source ID
- 10.1002/anie.201704472
Entities
People
- Eric Anslyn
- Xiaolong Sun
Organizations
- Defense Threat Reduction Agency
- Robert A. Welch Foundation
- University of Texas at Austin