Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals
Abstract
The hyperpolarization of heteronuclei via signal amplification by reversible exchange (SABRE) was investigated under conditions of heterogeneous catalysis and microtesla magnetic fields. Immobilization of [IrCl(COD)(IMes)], [IMes=1,3‐bis(2,4,6‐trimethylphenyl), imidazole‐2‐ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous SABRE (HET‐SABRE) catalyst that was used to demonstrate a circa 100‐fold enhancement of 15N NMR signals in 15N‐pyridine at 9.4 T following parahydrogen bubbling within a magnetic shield. No 15N NMR enhancement was observed from the supernatant liquid following catalyst separation, which along with XPS characterization supports the fact that the effects result from SABRE under heterogeneous catalytic conditions. The technique can be developed further for producing catalyst‐free agents via SABRE with hyperpolarized heteronuclear spins, and thus is promising for biomedical NMR and MRI applications.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 28, 2017
- Source ID
- 10.1002/anie.201705014
Entities
People
- Andrey Bukhtiyarov
- Boyd M Goodson
- Eduard Y. Chekmenev
- Igor Koptyug
- Jonathan Gesiorski
- Kirill V. Kovtunov
- Larisa Kovtunova
- Max E. Gemeinhardt
- Valery Bukhtiyarov
Organizations
- National Institutes of Health
- National Science Foundation
- Novosibirsk State University
- Russian Academy of Sciences
- Russian Center for Science Information
- Russian Science Foundation
- Siberian Branch of the Russian Academy of Sciences
- Southern Illinois University
- United States Department of Defense
- Vanderbilt University