Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid
Abstract
A new approach has been developed to prepare stable microbubbles (MBs) by interfacial nanoprecipitation of bioabsorbable polymers at air/liquid interfaces. This facile method offers robust control over the morphology and chemophysical properties of MBs by simple chemical modifications. This approach is amenable to large‐scale manufacturing, and is useful to develop functional MBs for advanced biomedical applications. To demonstrate this, a MB‐based intravenous oxygen carrier was created that undergoes pH‐triggered self‐elimination. Intravenous injection of previous MBs increased the risk of pulmonary vascular obstruction. However, we show, for the first time, that our current design is superior, as they 1) yielded no evidence of acute risks in rodents, and 2) improved the survival in a disease model of asphyxial cardiac arrest (from 0 to 100 %), a condition that affects more than 100 000 in‐hospital patients, and carries a mortality of about 90 %.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 02, 2018
- Source ID
- 10.1002/anie.201711839
Entities
People
- Alexis R. Cole
- Andrew T. Lock
- Brian D Polizzotti
- Jemima R. Lamothe
- John N Kheir
- Raymond P. Seekell
- Sarah Van Den Bosch
- Xiaoqi Tang
- Yifeng Peng
Organizations
- Boston Children's Hospital
- Congressionally Directed Medical Research Programs
- Harvard Medical School