Modulating the Folding Landscape of Superoxide Dismutase 1 with Targeted Molecular Binders
Abstract
Amyotrophic lateral sclerosis, or Lou Gehrig's disease, is characterized by motor neuron death, with average survival times of two to five years. One cause of this disease is the misfolding of superoxide dismutase 1 (SOD1), a phenomenon influenced by point mutations spanning the protein. Herein, we used an epitope‐specific high‐throughput screen to identify a peptide ligand that stabilizes the SOD1 native conformation and accelerates its folding by a factor of 2.5. This strategy may be useful for fundamental studies of protein energy landscapes as well as designing new classes of therapeutics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 25, 2018
- Source ID
- 10.1002/anie.201802269
Entities
People
- Anna K. Museth
- Beatriz Atsavapranee
- David N Bunck
- David Vandervelde
- James R. Heath
Organizations
- Army Research Office
- California Institute of Technology
- National Institute of Allergy and Infectious Diseases