Tunable Orthogonal Reversible Covalent (TORC) Bonds: Dynamic Chemical Control over Molecular Assembly
Abstract
Dynamic assembly of macromolecules in biological systems is one of the fundamental processes that facilitates life. Although such assembly most commonly uses noncovalent interactions, a set of dynamic reactions involving reversible covalent bonding is actively being exploited for the design of functional materials, bottom‐up assembly, and molecular machines. This Minireview highlights recent implementations and advancements in the area of tunable orthogonal reversible covalent (TORC) bonds for these purposes, and provides an outlook for their expansion, including the development of synthetically encoded polynucleotide mimics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 30, 2018
- Source ID
- 10.1002/anie.201808371
Entities
People
- Eric Anslyn
- James F Reuther
- Samuel D Dahlhauser
Organizations
- Defense Advanced Research Projects Agency
- Division of Materials Research
- National Institutes of Health
- Robert A. Welch Foundation
- University of Texas at Austin
- Yusuf Hamied Department of Chemistry