Seven‐Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification
Abstract
Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the highest total number of distinct reaction steps ever performed in continuous flow without conducting solvent exchanges or intermediate purification. Linezolid was obtained in 73 % isolated yield in a total residence time of 27 minutes, corresponding to a throughput of 816 mg h−1.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 08, 2019
- Source ID
- 10.1002/anie.201901814
Entities
People
- M. Grace Russell
- Timothy F. Jamison
Organizations
- Defense Advanced Research Projects Agency
- Massachusetts Institute of Technology