Onion‐like Multifunctional Microtrap Vehicles for Attraction–Trapping–Destruction of Biological Threats
Abstract
A multifunctional motile microtrap is developed that is capable of autonomously attracting, trapping, and destroying pathogens by controlled chemoattractant and therapeutic agent release. The onion‐inspired multi‐layer structure contains a magnesium engine core and inner chemoattractant and therapeutic layers. Upon chemical propulsion, the magnesium core is depleted, resulting in a hollow structure that exposes the inner layers and serves as structural trap. The sequential dissolution and autonomous release of the chemoattractant and killing agents result in long‐range chemotactic attraction, trapping, and destruction of motile pathogens. The dissolved chemoattractant (l‐serine) significantly increases the accumulation and capture of motile pathogens (E. coli) within the microtrap structure, while the internal release of silver ions (Ag+) leads to lysis of the pathogen accumulated within the microtrap cavity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 29, 2020
- Source ID
- 10.1002/anie.201913872
Entities
People
- Daniel Kupor
- Emil Karshalev
- Fanan Wei
- Farshad Tehrani
- Fernando Soto
- Joseph Wang
- Miguel Angel Lopez-Ramirez
- Songsong Tang
Organizations
- Defense Threat Reduction Agency
- University of California, San Diego