Parahydrogen‐Induced Hyperpolarization of Gases
Abstract
Imaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization. The level of nuclear spin polarization is typically very low, i.e., one hundred thousandth of the potential maximum at 1.5 T and a physiologically relevant temperature. As a result, MRI typically focusses on imaging highly concentrated tissue water. Hyperpolarization methods transiently increase nuclear spin polarizations up to unity, yielding corresponding gains in MRI signal level of several orders of magnitude that enable the 3D imaging of dilute biomolecules including gases. Parahydrogen‐induced polarization is a fast, highly scalable, and low‐cost hyperpolarization technique. The focus of this Minireview is to highlight selected advances in the field of parahydrogen‐induced polarization for the production of hyperpolarized compounds, which can be potentially employed as inhalable contrast agents.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 11, 2020
- Source ID
- 10.1002/anie.201915306
Entities
People
- Baptiste Joalland
- Eduard Y. Chekmenev
- Igor Koptyug
- Kirill V. Kovtunov
- Marianna Fekete
- Simon B. Duckett
- Thomas Theis
Organizations
- Edward Mallinckrodt Jr. Foundation
- International Tomography Center
- Medical Research Foundation
- National Institute of Biomedical Imaging and Bioengineering
- National Science Foundation Directorate for Mathematical & Physical Sciences
- North Carolina State University
- North Carolina Translational and Clinical Sciences Institute, University of North Carolina at Chapel Hill
- Novosibirsk State University
- Oak Ridge Associated Universities
- Russian Academy of Sciences
- Russian Center for Science Information
- Russian Science Foundation
- University of York
- Wayne State University
- Wellcome