Biomolecular Densely Grafted Brush Polymers: Oligonucleotides, Oligosaccharides and Oligopeptides
Abstract
In this Minireview, we describe synthetic polymers densely functionalized with sequence‐defined biomolecular sidechains. We focus on synthetic brush polymers of oligonucleotides, oligosaccharides, and oligopeptides, prepared via graft‐through polymerization from biomolecule functionalized monomers. The resulting structures are brush polymers wherein a biomolecular graft is positioned at each monomer backbone unit. We describe key synthetic milestones, identify synthetic opportunities, and highlight recent advances in the field, including biological applications.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 28, 2020
- Source ID
- 10.1002/anie.202005379
Entities
People
- Claudia Battistella
- Hao Sun
- Maria A. Vratsanos
- Max Wang
- Nathan C. Gianneschi
- Or Berger
- Wonmin Choi
Organizations
- Army Research Office
- National Institutes of Health
- National Science Foundation of Sri Lanka
- Northwestern University