Ultrasound‐Responsive Aqueous Two‐Phase Microcapsules for On‐Demand Drug Release
Abstract
Traditional implanted drug delivery systems cannot easily change their release profile in real time to respond to physiological changes. Here we present a microfluidic aqueous two‐phase system to generate microcapsules that can release drugs on demand as triggered by focused ultrasound (FUS). The biphasic microcapsules are made of hydrogels with an outer phase of mixed molecular weight (MW) poly(ethylene glycol) diacrylate that mitigates premature payload release and an inner phase of high MW dextran with payload that breaks down in response to FUS. Compound release from microcapsules could be triggered as desired; 0.4 μg of payload was released across 16 on‐demand steps over days. We detected broadband acoustic signals amidst low heating, suggesting inertial cavitation as a key mechanism for payload release. Overall, FUS‐responsive microcapsules are a biocompatible and wirelessly triggerable structure for on‐demand drug delivery over days to weeks.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 16, 2022
- Source ID
- 10.1002/anie.202116515
Entities
People
- Kelia A Human
- Margaret A. Jakus
- Parag V. Chitnis
- Rachel D. Field
- Samuel K Sia
- Xiaoyu Chen
- Xuanhe Zhao
Organizations
- Columbia University
- Defense Advanced Research Projects Agency
- George Mason University
- Massachusetts Institute of Technology
- National Center for Advancing Translational Sciences