Quinone propionic acid‐based redox‐triggered polymer nanoparticles for drug delivery: Computational analysis and in vitro evaluation
Abstract
Redox‐responsive polymers with pendant quinone propionic acid groups as a redox trigger were optimized by computational modeling to prepare efficient redox‐triggered polymer nanoparticles (NPs) for drug delivery. Lipophilicities at complete reduction of redox‐responsive polymers (In vitro drug release profiles demonstrated the NPs to release >80% of paclitaxel over 24 h at a simulated redox‐state compared with 26.5 to 41.2% release from the control. Cell viability studies revealed that the polymer was nontoxic and the NPs could release paclitaxel to suppress breast cancer cell growth. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40461.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 01, 2014
- Source ID
- 10.1002/app.40461
Entities
People
- Fakhri Mahdi
- Ho‐wook Jun
- Jungeun Bae
- Lingzhou Jiang
- Manal A. Nael
- Patrick Taejoon Hwang
- Robert J. Doerksen
- S. Narasimha Murthy
- Seongbong Jo
- Wael M. Elshamy
- Yu‐dong Zhou
Organizations
- National Science Foundation
- United States Department of Defense
- University of Alabama at Birmingham
- University of Mississippi