Intraarticular injection of heparin‐binding insulin‐like growth factor 1 sustains delivery of insulin‐like growth factor 1 to cartilage through binding to chondroitin sulfate
Abstract
Insulin‐like growth factor 1 (IGF‐1) stimulates cartilage repair but is not a practical therapy due to its short half‐life. We have previously modified IGF‐1 by adding a heparin‐binding domain and have shown that this fusion protein (HB‐IGF‐1) stimulates sustained proteoglycan synthesis in cartilage. This study was undertaken to examine the mechanism by which HB‐IGF‐1 is retained in cartilage and to test whether HB‐IGF‐1 provides sustained growth factor delivery to cartilage in vivo and to human cartilage explants.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 30, 2010
- Source ID
- 10.1002/art.27709
Entities
People
- Ada A. Cole
- Alan J. Grodzinsky
- Anna H. K. Plaas
- Kiersten Cummings
- Parth Patwari
- Rachel E. Miller
- Richard T. Lee
Organizations
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Science Foundation