Gr‐1highCD11b+ Cells Suppress B Cell Differentiation and Lupus‐like Disease in Lupus‐Prone Male Mice
Abstract
Systemic lupus erythematosus (SLE) develops much more readily in females than in males. Previous research has focused primarily on identifying mechanisms pertinent to the pathology in females. The aim of the current study was to delineate active protective mechanisms in males. We present evidence of a new male‐associated mechanism of protection against the development of lupus‐like disease in lupus‐prone (NZB × NZW)F1 mice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 26, 2013
- Source ID
- 10.1002/art.38048
Entities
People
- Abhishek Trigunaite
- Anne Song
- Ayesha Khan
- Evan Der
- Sanjay Varikuti
- Trine N. J⊘rgensen
Organizations
- Cleveland Clinic
- United States Department of Defense