Use of Recombinant Human Stromal Cell–Derived Factor 1α–Loaded Fibrin/Hyaluronic Acid Hydrogel Networks to Achieve Functional Repair of Full‐Thickness Bovine Articular Cartilage Via Homing of Chondrogenic Progenitor Cells
Abstract
Articular cartilage damage after joint trauma seldom heals and often leads to osteoarthritis. We previously identified a migratory chondrogenic progenitor cell (CPC) population that responds chemotactically to cell death and rapidly repopulates the injured cartilage matrix, which suggests a potential approach for articular cartilage repair. This study was undertaken to determine whether recombinant human stromal cell–derived factor 1α (rhSDF‐1α), a potent CPC chemoattractant, would improve the quality of cartilage regeneration, hypothesizing that increased recruitment of CPCs by rhSDF‐1α would promote the formation of cartilage matrix upon chondrogenic induction.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 27, 2015
- Source ID
- 10.1002/art.39049
Entities
People
- Dongrim Seol
- Hongjun Zheng
- James A. Martin
- Joseph A. Buckwalter
- Marc J Brouillette
- Yin Yu
Organizations
- United States Department of Defense
- University of Iowa