Identification of a Novel Toll‐like Receptor 7 Endogenous Ligand in Rheumatoid Arthritis Synovial Fluid That Can Provoke Arthritic Joint Inflammation
Abstract
Levels of Toll‐like receptor 7 (TLR‐7) are elevated in rheumatoid arthritis (RA), but the impact on RA is unknown because the endogenous ligand for TLR‐7 has not been identified. The aim of this study was to identify a TLR‐7 endogenous ligand and to determine its role in the pathogenesis of RA.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 27, 2016
- Source ID
- 10.1002/art.39544
Entities
People
- Abdul B. Essani
- Hatem A. Elshabrawy
- Michael V. Volin
- Nadera Sweiss
- Seung‐jae Kim
- Shiva Arami
- Shiva Shahrara
- Suncica Volkov
- William Swedler
- Zhenlong Chen
Organizations
- Midwestern University
- National Institutes of Health
- United States Department of Defense
- University of Illinois at Chicago